Module 2

MDMA Pharmacodynamics and Pharmacokinetics

Module Description

In the last module, we learned about the historical and legal context as well as some foundational aspects about the molecular structure of MDMA. In this module, we will be looking at MDMA’s pharmacodynamics or, in other words, the effects that MDMA has on the body as well as the pharmacokinetics, or how MDMA is absorbed and metabolized by the body. We will explore the indications that MDMA-assisted therapy seeks to treat, the mechanisms of action, and the dose ranges of MDMA in these contexts.

Module Description

In the last module, we learned about the historical and legal context as well as some foundational aspects about the molecular structure of MDMA. In this module, we will be looking at MDMA’s pharmacodynamics or, in other words, the effects that MDMA has on the body as well as the pharmacokinetics, or how MDMA is absorbed and metabolized by the body. We will explore the indications that MDMA-assisted therapy seeks to treat, the mechanisms of action, and the dose ranges of MDMA in these contexts.

Learning Outcomes

Upon successful completion of the course, you will be able to:

  • Explain the risks, benefits, and pharmacological knowledge of MDMA in plain language to interdisciplinary colleagues and to clients as part of the informed consent process.

  • Describe dosing considerations, expected duration, metabolism, and expected intensity of MDMA.

  • Discuss key areas of research on MDMA.

  • Explain the pharmacodynamics and pharmacokinetics of MDMA.

  • Describe the subjective and physiological effects and adverse effects of MDMA according to different dose ranges as they relate to psychedelic-assisted therapy.

  • Explain the primary effects and mechanisms of action of MDMA on the brain, including connectivity in the brain and activation of serotonin receptors.

  • Explain for which indications MDMA is being investigated for treatment.