While there are a wide array of adverse effects, the adverse effects depend on the dose level and can vary significantly from person to person.
The adverse effects listed in this section are not an exhaustive list, however they are the most common adverse effects or the adverse effects that cause the greatest concern in a clinical setting.
Please ensure that you read through all tabs before proceeding.
References
Abbar, M., Demattei, C., El-Hage, W., Llorca, P. M., Samalin, L., Demaricourt, P., . . . Jollant, F. (2022). Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial. BMJ, 376, e067194. https://doi.org/10.1136/bmj-2021-067194
Ceban, F., Rosenblat, J. D., Kratiuk, K., Lee, Y., Rodrigues, N. B., Gill, H., . . . McIntyre, R. S. (2021). Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. CNS Drugs, 35(9), 925-934. https://doi.org/10.1007/s40263-021-00846-5
Grunebaum, M. F., Galfalvy, H. C., Choo, T. H., Keilp, J. G., Moitra, V. K., Parris, M. S., . . . Mann, J. J. (2018). Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam- Controlled Randomized Clinical Trial. Am J Psychiatry, 175(4), 327-335. https://doi.org/10.1176/appi.ajp.2017.17060647
Janssen Inc. (2020). Product Monograph: NSPRAVATO ® Esketamine Nasal Spray. https://www.janssen.com/canada/sites/www_janssen_com_canada/files/prod_files/live/spravato_cpm.pdf
Psychedelic.support (N.d.). Little book of psychedelics. https://psychedelic.support/education/free-courses/
Sandoz Canada Inc. (2015). Product Monograph: Ketamine Hydrochloride Injection USP & Ketamine Hydrochloride Injection SDZ. https://www.sandoz.ca/sites/www.sandoz.ca/files/Ketamine_HCl_PMe_20150506.pdf
Witt, K., Potts, J., Hubers, A., Grunebaum, M. F., Murrough, J. W., Loo, C., . . . Hawton, K. (2020). Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta- analysis of treatment trials. Aust N Z J Psychiatry, 54(1), 29-45. https://doi.org/10.1177/0004867419883341