Ketamine blocks NMDA receptors, leading to a surge of glutamate release. This causes rapid mood improvements by restoring glutamatergic signaling.
Ketamine turns off “burst mode” in the lateral habenula (the “anti-reward” center in the brain). This makes it easier for you to approach and process negative emotions that have otherwise been too difficult for you to access.
Ketamine stimulates brain-derived neurotrophic factor (BDNF), leading to the creation of new neurons and new connections between neurons.
Ketamine interrupts connection between the cerebral cortex and limbic system, causing a “time out” from regular thinking patterns that are keeping you stuck.