Another consideration for assessment is contraindications and concomitant medications and supplements. While psilocybin is generally considered safe in a clinical setting (Little book of psychedelics), there always exist the possibility of interactions with other medications or adverse effects for clients with existing conditions or predispositions for certain conditions.
Health professionals should be mindful of possible interactions and consult a physician or pharmacist on the possibility of interactions. Any change in medication should be overseen by a licensed medical provider. Use of psychedelic medicines other than ketamine in a clinical setting is very new and has for many years been limited to highly controlled clinical trials. Not all concomitant medications have been studied.
The following are contraindications for psilocybin administration.