Another consideration for assessment is contraindications and concomitant medications and supplements. MDMA is likely to interact with many psychiatric medications (MAPS, 2021); however, MDMA may be used safely with some previously approved medications for post-traumatic stress disorder (PTSD), such as paroxetine (an SSRI antidepressant), though it may cause attenuation or reversion of certain subjective effects associated with MDMA administration (Segura et al., 2005).
Health professionals should be mindful of possible interactions and consult a physician or pharmacist on the possibility of interactions. Any change in medication should be overseen by a licensed medical provider. Use of psychedelic medicines other than ketamine in a clinical setting is very new and, has for many years, been limited to highly controlled clinical trials. Not all concomitant medications have been studied.
The following are contraindications for MDMA administration.